Causes And Effects Of Limk1 - 1300 Words

Results Expression of LIMK1 was up-regulated in TCGA breast cancer database The expression of LIMK1 in breast cancer was checked in oncomine website (https://www.oncomine.org/). The TCGA database results (Figure 1) showed that LIMK1 was high expressed in different breast cancer type, including intraductal cribriform breast adenocarcinoma, invasive breast carcinoma, invasive lobular breast carcinoma and mixed lobular and ductal breast carcinoma. These results indicated that LIMK1 could be an oncogene in breast cancer. Mir-138-5p targeted LIMK1 and inhibited the expression of LIMK1 Several databases indicated that miR-138-5p could target LIMK1, such as TargetScan, PicTar and miRwalk, to regulate LIMK1/CFL1 signal pathway to function as a†¦show more content†¦Western blot showed that miR-138-5p could also inhibit the expression of PCNA, which was thought to be a proliferation biological marker13 .These results showed that miR-138-5p inhibited the proliferation of breast cancer cells. Mir-138-5p inhibited migration and invasion of breast cancer cells As shown in Figure 5A, the wound healing assay showed that over-expression of miR-138-5p in MDA-MB-231 breast cancer cells healed more slowly compared to NC group. At 24 h, in miR-138-5p treatment group, there was still 50% space not migrated by MDA-MB-231 cells while in NC group, the MDA-MB-231 cells have already healed already. Besides, the transwell assay showed over-expression of miR-138-5p also decreased the migrating and invasive cells (Figure 5B and 5C). It is well known that MMP2 and MMP9 are usually used as indicators of metastasis because they are important for metastatic cancer cell invading the basement membrane14, 15.Therefore we chose MMP2 and MMP9 as the biomarkers to reflect migration and invasion of metastatic breast cancer cells. As shown in Figure 5C and 5D, we found that miR-138-5p could significantly inhibit the protein level of MMP2 and MMP9 both in MDA-MB-231 and HCC1937 two breast cancer cellines. These results showed that over-expression of miR-138-5p inhibit ed migration and invasion of breast cancer cells. Mir-138-5p arrested breast cancer cells into G0/G1 phase After over-expression of miR-138-5p, MDA-MB-231 cells wereShow MoreRelatedThe Discovery Of The Small Rna Lin 4 Essay2141 Words   |  9 PagesFenelon et al., 2011) and enhancement of memory on several behavioral tasks (Bredy et al., 2011). Due to the discovery of non-canonical functions for Dicer, studies using Dicer knockouts should be carefully interpreted and verified for non-specific effects (Fukagawa et al., 2004; Kanellopoulou et al., 2005; Shapiro et al., 2010; Babiarz et al., 2011; Kaneko et al., 2011). In accordance with loss of function studies, dysfunction of the miRNA machinery and proteins associated with it has been implicatedRead MoreA Genetic Review Of Schizophreni Research Progress Of Chromosomes 22 And 83307 Words   |  14 PagesMedications are most commonly prescribed are antipsychotics. These affect the release of neurotransmitters in the brain such as dopamine and serotonin, which are thought to control symptoms of schizophrenia (Mayo Clinic Staff). Medications can often cause side effects that render patients unwilling to continue taking them. In these cases, treatment has to be forced upon the patients. The goal in medication treatment is to control the signs of schizophrenia with as low a dosage as possible. Therapy is another

The American Dream - 1678 Words

The American Dream is an idea that has always been different throughouttime. It changes in diverse forms and in the end involves success. The American Dream was a phrase used by the American people and peoplewanting to become American. It was always the idea that you can become a success. This is true in a partial way, but the true American Dream is that with somework and determination anyone can build themselves up in the economic classsystem. The 80 s was an eye opener to a lot of new things, new music, new styles, new points of view on life and new technology. Music was a big hit for the 80 s and so was the technology. A home, family, job and fun was basically what everyone needed to live ahappy life. In the 80 s, people saw the American dream, as a simple task of success andthose years defined them. They were the generation in between differences and facing disagreement andnot turning our backs. The 80 s may have made them idealistic, but it s idealism that will push themand be passed on to their children, the first children of the twenty-first century. Yolanda McClain a 54 year old African American mother of 3 had a dream of providing for her 3 kids. Yolanda follows God with a social economic status of middle class her dream almost came true. Yolanda s first child finished school and now is enrolled in medical school. Yolanda quotes And the other two can t keep a job worth shit Christian and Muslim Aleshia Mcmath, a 39 year old mother with anShow MoreRelatedImmigrants And The American Dream1362 Words   |  6 PagesImmigrants and the American Dream In the article â€Å"The American Dream†, by James Truslow Adams in The Sundance Reader book, he stated that the American dream is that dream of a land in which life should be better and richer and fuller for everyone, with opportunity for each according to ability or achievement. It is a difficult dream for the European upper classes to interpret adequately, and too many of us ourselves have grown weary and mistrustful of it. It is not a dream of motor cars and highRead MoreThe American Dream By Kimberly Amadeo1637 Words   |  7 PagesNowadays, a large number of people migrate to the United States to work and achieve the American Dream. According to the Article â€Å"What is the American Dream?† by Kimberly Amadeo, â€Å"The American Dream was first publicly defined in 1931 by James Truslow Adams in Epic of America. Adam’s often-repeated quote is, ‘The American Dream is that dream of land in which life should be better and richer and fuller for everyon e, with opportunity for each according to ability or achievement.’† There are many peopleRead MoreAnalysis Of The Movie The American Dream 754 Words   |  4 Pages Nyreel Powell Ms. Jones American Literature 1 June 2015 The American dream in A Raisin in the Sun Have you ever had a dream and it didn’t come how you wanted it to be? Have you ever had accomplishments that you wanted to achieve but people were getting in the way of them? The four main characters in this book all have good dreams but there are people in the way of getting to those dreams or their dream is too high to accomplish. 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Many great films and works of literature were created to show case all the different ideas people have for their American Dream. The film â€Å"Grapes of Wrath† directed by John Ford and the poem â€Å"I Will Fight No More Forever† by Chief Joseph, both depictRead More Destruction of the American Dream Essay2145 Words   |  9 PagesDestruction of the American Dream I’ve talked about it in the past, the destruction of the American Dream. Always, there have been papers, writings, and thoughts that quantify a particular section of its ultimate demise, be it due to money, education, or sexuality. Maybe the destruction cannot be viewed as a singular event or cause. Perhaps instead it must be examined as a whole process, the decay and ultimate elimination of a dream. Self destruction, if you will†¦ Mr. Self Destruct Read MoreSuccess As One Of The American Dream1137 Words   |  5 PagesApril 2015 Success as One of The American Dream When we hear the word â€Å"success†, we often think of wealth and money. To some people, the embodiment of being success is earning a lot of money. In fact, the concept of success is primarily based on how much money a person earns. However, each person views the definition of success differently. One way to define success is something that has more to do with flash than it does with substance. John Wooden, an American basketball player and coach viewRead MoreJim Cullen And The American Dream2081 Words   |  9 Pages The American Dream, as defined by Cullen, is starting your goal off with a little and ending with more; it s like a business, you invest in it in order to gain more money. Usually, people will define the American Dream as being able to achieve your goal because everyone is offered opportunities. Cullen does acknowledge that people are born with different opportunities, so he talks about the good life. The good life describes different factors that determine your opportunities. Throughout the otherRead MoreFactors Influencing The American Dream1834 Words   |  8 Pagesindividual to succumb or to not succumb to the seductions of crime. These three factors are brilliantly portrayed in the television show, Breaking Bad and the novel, The Stick Up Kids. The American Dream is what many American citizens strive for. However, not all of those citizens are able to achieve the American Dream through a legal pathway. The reason an indivudal may not being able to do so is because of his or her background factors. It is important to note that background factors are a fractionRead MoreShark Tank And The American Dream1755 Words   |  8 PagesShark Tank and The American Dream The TV show Shark tank embodies everything the American dream represents. The show obtains successful Entrepreneurs ready to invest their own money into other Americans wanting to be just like them, reaching the American dream and become a successful entrepreneur. The show presents entrepreneurs working towards the goal of creating a business to not only gain wealth but also change the way we live today. The show is to keep the American dream alive and well while

Corporate Venturing Of Samsung Company †MyAssignmenthelp.com

Question: Discuss about the Corporate Venturing Of Samsung Company. Answer: Introduction Samsung Company is an international corporation that is involved in producing electronic products such as radios, televisions, and phones. Lee Byung-Chul founded the Samsung Company in 1938 as a traditional company. The name Samsung literally means Korean hanja, this means Tri-Star implying something big and powerful. Samsung Company has been in the international electronics industry for the last decades because of its prevailing technological intervention and innovation, the company main competitors in the market include Sony, Apple Inc., and Motorola(Lee, 2006). Despite operating in a competitive market, Samsung Company has posted a KRW 53.33 trillion in consolidated revenue, the company has also reported over KRW 9.22 trillion operating profit for the quarter. In 2016, the company reported KRW 201.87 trillion and operating of KRW 29.24 trillion. The fourth quarter earnings in 2016 were driven by the essential business strategies inaugurated by the company top management(Mitchell, 2010). The company success is ordained by the corporate venturing on different business components mainly on the Memory and Display Panel segment, their manufactures are OLED and LCD screens. The excellent sales value is contributed by the high performance of the memory products, large shipment of large-size UHD panels and OLED. These business strategies led to increase in company operating profits(Hayton, 2005). Samsung Logo A business logo has been defined as a source of every business success. Samsung Company Logo has played a fundamental role in ensuring that the corporation name is known in the work technological industry, it is one of the models of marketing that is used by the company to gain more success. According to the study, the first enlargement of the company image was started in 1993. Samsung Company has driven its business strategies that will enhance corporate identity of its products in the market(Madhavaram, Badrinarayanan, McDonald, 2005). Currently, the company is using a blue background that was designed to show the indefinite shape that elaborates on the impression of modernization as well as advanced business corporate strategies. The consumers in the market recognize the company products by viewing at the logo(Percy, 2014). Samsung Company has released different types of products that are considered to meet the demands and needs of the consumers in the market. The company informed its all new products by using a business slogan, Inspire the World, Create the Future, this slogan as used by the Samsung Company implies the essence of chasing the future with new inspirable products(Hayton, 2005). The slogan is used by the company to inform its consumers that they are moving forward towards improving its products and brands in the market. Theoretical Concepts Since the foundation of the Samsung Company in 1969, the company has counted its success based on many business components and concepts that are critical to any business enterprise, especially those that operate in the large market. The company has expanded in many areas of business, the executives of the company have capitalized on strategic measures that are recognized to have positive influential approach to the business organization(Banerjee, 2009). Marketing Strategies Management is explained as the process that entails coordinating the fundamental activities of the business organization with an aim of accomplishing the strategic goals and objectives of the company(Pride Ferrell, 2016). Management comprises the vital approaches of marketing, marketing is outlined as a strategic management approach that involves the process of transforming goods from their original concept to the consumer. Marketing strategies comprise the implementation of marketing mix approach, where 4ps are considered as the essential components(Pitts, 2017). Marketing communication Marketing is a fundamental part of management that comprises the process through which goods and services are transformed from their original concepts to the consumers, it entails the process of coordinating the four components of marketing, the four elements are the product, price, place, and promotion(Madhavaram, Badrinarayanan, McDonald, 2005). Marketing communication is part of marketing that ensures that all the important information reasonably linked together with the purpose of accomplishing the company goals and objectives(Lee, 2006). The marketing communication is described as the marketing component that enhances that all the marketing promotional tools are harmonized collectively. Marketing communication is the important part of organization management strategies, it defines the communication channels, media that are used to convey important information to the consumers(Percy, 2014). Samsung Company has confirmed the importance of implementing marketing and communication policies, the company has coordinated all marketing approaches that are recognized to positively influence the company business activities. Advertisement The advertisement is the main element of marketing communication. It entails the process of using TV, radio, and posters to promote products and services. The Samsung Company certifies the importance of advertisement marketing approach The Company has made TV advertisement to promote brand awareness in the market. Samsung Company and Chile Worldwide Agency have recently focus to implement the advertising campaigns about its new products in the market(Banerjee, 2009). Sales promotion Sales promotion in marketing acts as the pivot of the company success. Marketing communication in an organization advocates the process of implementing sales promotion as a fundamental constituent of marketing. The Samsung Company has offered bonus to the consumers who purchase new products and trading-off their products with previous one. By implementing on sales promotion, the consumers are allowed to receive the value of their products(Madhavaram, Badrinarayanan, McDonald, 2005). Internet marketing The Internet is considered as an essential element of marketing communication in a business organization. Samsung Company has capitalized on internet marketing where social media is considered as a primary element of internet market. YouTube and Facebook are the largest social media that are used by Samsung Company to attained its marketing objectives(Singhania, 2006). Samsung innovative Strategy Every electronic customer knows about Samsung Company which is a leading electronics company in the world market. Inspire the World, Create the Future is a slogan that has made the company focus on the innovative business strategies that will ensure the company is gaining a competitive advantage in the market(James , 2011). Many critics have arisen arguing that Samsung Company is copying its designs from Apple Inc. which is the main competitor in the market. The company innovation in screen technology, batteries, TVs, and chip designs is known to be exceptional in the market as compared with other players in the market. The Samsung Company innovative strategy is drawn from earlier 1990s and 2000 when they started to adopt a comprehensive systemic approach to innovation, this earlier capitalization of innovative approaches has contributed to the current business success(Karimi Walter, 2016). Samsung Company innovative strategy has natured a good relationship with Russian Academy of Science, the two parties agreed on major approaches that may lead to competitive advantage. Innovation at Samsung is promoted by the support that is given by Korea Government, the government provided incentives to Korean business enterprises to develop projects under the Academy research(Mitchell, 2010). Samsung Company is known to be part of the agencies that help Academy research as it increases its patent count as well as exploiting its interventions of ideas. The corporations of Russian Academy of Science with Korean Government have obliged the Samsung Company to cooperatively venture their business activities to other small business organization. Samsung Company totally different strategy from Apple Innovation strategy at Samsung Company is described as a model that has made the company to be the leading electronic producer in the industry, this business model has kept the competitors at a bay. Apple Inc. is the largest market player in the technological market, it is one of the market giants that compete with Samsung Company. In the last few years, Samsung Company has been working extensively to catch up with the Smartphone market. The Samsung Company has inaugurated new strategies of improving the existing product in the market. In 2013, Samsung Company introduced new product, the Galaxy S4 smartphone(Max, 2013). The Samsung Galaxy S4 smartphone flagship was the latest product in the market, it had a massive screen and impressive features. The product also had friendly software that allows the consumers to use the product effectively. The present business environment puts Samsung Company in a sea of challenges and defeats, the aspects of globalization, as well as the technological changes, accelerate the challenges and defeats affecting the Samsung Company. Innovative strategy used by Samsung Company in the market is embed and inside innovation strategies that truly contribute to the game-changing in the market. Research Approach The mobile manufacturers are currently operating in highly and large competitive business environment. The technology companies are developing new technology product that is considered too important to the 21st-century market environment. Innovation and release of new product designs evolutes through many technological advancements. Every market player in the technology industry is extensively working to maintain and improve their market positions(John , 2012). The research report contents are projected from the different departments of the organizations, including marketing sector. The foundation of the research is based on the geographical division of Samsung Company and their business activities. Samsung Company is a South Korean corporation that operates in 65 countries with over 170, 000 employees working for the company. The business strategy of Samsung Company is focus to present an interesting case since it pursuing both product differentiation approaches and cost leadership in the market(James , 2011). Data Analysis And Discussion: Entrepreneurial Intensity The entrepreneurial intensity is a business strategic management approach that defines the levels of entrepreneurship within a given organization. An entrepreneurial intensity is comprehended when its orientation to the business is associated with the performance of the company. Entrepreneurship is a foundation aspect of EI as a business strategic management approach, it is defined as the process of accumulating the available resources and intercepting the ideas to exploit a business opportunity(Morris, Kuratko, Covin, 2010). Measuring innovation at Samsung Company The core factor that has kept the Samsung Company on the move of being among the leading technology companies in the market is the fact that it capitalizes on market research. This implies that the company is primary defines its success by conducting technical research in the market with regard to the needed products(Kuratko, 2016). Samsung Company spends more time doing research as compared to other market players such as Apple Inc., Sony, and Microsoft. Inspire the World, Create the Future, is a business slogan that is used by Samsung Company anticipate for its future performance in the market. The company has focus to adopt the corporate venturing strategic management approach. The future investment adopted by the company has allowed the company to be the leading producer in manufacturing of memory chips, Phones, TVs, multimedia, and LCD. Samsung Company has been able to maintain its entrepreneurial drives as it implements on the essential entrepreneurial aspects. Samsung innovation is one of the business aspects that has kept the company to kept competitors at bay. Over 170,000 employees who are spread in 18 research centers in the world succeed innovation strategies for the company(Karimi Walter, 2016). New path to sustainable competitive advantage Every business organization in the current business environment is exploiting on different measures that will contribute to their success. Primarily business environment is constituted by different aspect that may prevent the business organization to gain competitive advantage in the market. Samsung Company is in the front line of adopting new measures that will provide solutions to the business challenges. Entrepreneurship Intensity is a business strategy that has allowed Samsung Company to gain a sustainable competitive advantage in the market. The process of obtaining business advantage in the market confirms the aspect of focusing on the entrepreneurial characteristics. The expedition of competitive advantage in the market obliges company and the managers to inaugurate on the entrepreneurial features. The managers of Samsung Company are known to adapt existing and new market with entrepreneurial characteristics. Aggressiveness, innovativeness, and adaptability are the entrepreneurial aspects installed by the Samsung Company(Max, 2013). Climate for Corporate Entrepreneurship In the current business environment, the business organization is focused on the entrepreneurial behaviors. Samsung Company management led by Lee Byung-Chul are working appropriately to create entrepreneurial climate. Samsung Company has gained the reputation of being a fast follower after Apple Inc, the Samsung Company is dispersedly adopting the approach of creating a corporate entrepreneurial climate by innovative and developing new products(Max, 2013). The corporate entrepreneurship climate of Samsung Company is promoted by the support from the Korean government that provides free tax incentives as well as offering investment capitals. Unlike other players in the market, Samsung has focused mainly on the existing markets, the company has studied the markets and innovating inside them(Karimi Walter, 2016). Conclusion Samsung Company is an international company that is involved in production of electronic products. Lee Byung-Chul founded the company in 1938 as a trading company. Corporate venturing is a fundamental business approach that allows the business organization to focus on the future investment. Entrepreneurship and innovation are the key aspects of corporate venturing. Inspire the World, Create the Future, is a business slogan that is used by the Samsung Company to focus on the future investment. The slogan is used by the Samsung Company to improve the existing product as it also produces inspirable products. Marketing is part of the management, it involves the process where the materials are transformed from their original concept to the consumer concepts. Marketing involves the coordination of 4 marketing mix, this strategies involves, product, price, promotion and place. Marketing communication is an element of marketing that constitutes the process of coordinating all the essential information to the consumers. Innovation and entrepreneurship are the key features that contributes to the success of an organization. Innovation strategies at Samsung Company contribute to sustainable business advantage. Corporate entrepreneurship allows the business organization and mangers to create a productive organizational behavior. References Banerjee, S. (2009). Marketing communication through brand placement: A strategic roadmap. Journal of Marketing Communication, 5(2), 4-22. Hayton, C. J. (2005). Promoting corporate entrepreneurship through human resource management practices: A review of empirical research. James , M. (2011, October ). Samsungs Corporate Venturing Strategy. Retrieved October 10, 2011, from https://hbr.org/2011/10/corporate-venturing-rhymes-wit John , D. (2012). Research-Methodology. Samsung Electronics. Retrieved May 3, 2012 , from https://research-methodology.net/samsung-electronics/ Karimi , J., Walter, Z. (2016). Corporate entrepreneurship, disruptive business model innovation adoption, and its performance: The case of the newspaper industry. Long Range Planning, 49(3), 342-360. Kuratko, D. F. (2016). Corporate entrepreneurship. The Routledge Companion to the Makers of Modern Entrepreneurship, 154. Lee, D. (2006). Samsung Electronics: the global inc. LEE Dongyoup. Madhavaram, S., Badrinarayanan, V., McDonald, R. (2005). Integrated marketing communication (IMC) and brand identity as critical components of brand equity strategy: A conceptual framework and research propositions. Journal of Advertising, 34(4), 6. Max, N. (2013, March 15). Samsung Has A Totally Different Strategy From Apple, And It's Working Great. Retrieved March 15, 2013, from https://www.businessinsider.com/samsung-corporate-strategy-2013-3?IR=T Mitchell, T. (2010). Samsung Electronics: And the Struggle for Leadership of the Electronics Industry,. Wiley Publications. Morris, M. H., Kuratko, D. F., Covin, J. G. (2010). Corporate entrepreneurship innovation. Cengage Learning. Percy, L. (2014). Strategic integrated marketing communications. Routledge. Pickton, D., Broderick, A. (2001). Integrated marketing communications. Harlow:: Prentice Hall. Pitts, B. (2017). Sport Marketing. Understanding Sport Management: International Perspectives. Pride, W. M., Ferrell, O. C. (2016). Foundations of marketing. Cengage Learning. Samsung. (2017, January 24). Samsung Electronics Announces Fourth Quarter and FY 2016 Results. Retrieved January 24, 2017, from https://news.samsung.com/global/samsung-electronics-announces-fourth-quarter-and-fy-2016-results Singhania, P. (2006). Branding and its Competitive Advantage in Consumer Electronics Industry, Dissertation for M. A. Management Degree. Urban, B., Wood, E. (2017). The innovating firm as corporate entrepreneurship. European Journal of Innovation Management.

Foundation For Toyota Best Automobile Brand -Myassignmenthelp.Com

Question: Discuss About The Foundation For Toyota Best Automobile Brand? Answer: Introduction As the number of businesses increases globally, so is competition in every sector thus making research a fundamental requirement every business must conduct so as to retain its market position. The automobile industry has been at the forefront of this initiative due to the increasing competition as well as pressure from social, political and environmental fronts. This has resulted in Automobile companies needing to adopt major reforms aimed at addressing the concerns but these have only been possible through the application of in-depth research (Wickham, 2016). For this analysis, the company Toyota shall be analysed to determine research strategies applied by the company with regard to addressing social, political and environmental concerns raised in recent years. While the pressure has been intense on most automobile companies, Toyota has demonstrated the most adaptability with regard to adopting the changes thus making it the most suitable research subject to be used in this analysis. Toyota has been in operation since 1956 and grown to be among the largest automobile companies globally thus placing it at the forefront of addressing social corporate initializes (Chambers, 2018). The company has also experienced several scandals in the past which have highlighted the companys reputation which further makes the company attractive to perform an applied research study to determine important approaches adopted by the company to address the social, political and environmental pressures experienced by the company References: Wickham, H. (2016). ggplot2: elegant graphics for data analysis. Springer. Chambers, J. M. (2018).Graphical methods for data analysis. CRC Press.